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George's mother (Debra Monk) returns to Seattle Grace after undergoing a botched surgery at another hospital, and the doctors wax nostalgic about George. Meanwhile, a harvested heart continues to beat outside its body; a new pediatric fellow excites Arizona and arouses Alex's insecurity; Jackson allows his suspicions about Mark and Lexie interfere with his work; and Henry and Teddy fight when he tells her he wants to go to medical school. Guest stars include Alfre Woodard.